If I were the Bills' GM... MY FIRST PICK would be a QB! If I have to trade up, then that's what I would do. Heck, I might pick QB in the first, then the next year pick one in the second and the next year in the third... by then you know if your first has worked... and if not, I go right back to QB in the first (if I'm still around).
We have been looking for a QB for the better part of a decade... we drafted Collins to be the replacement for Kelly and we drafted JP. Those have been the only two legitimate 1st round, franchise-type QBs we have taken a run at. If I'm Nix... I would have done this ALREADY, but certainly this year!